Population
Guinea-pig isolated atria and rat isolated caudal artery preparations
Design
Preclinical
Authors
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Supports local Ang II modulation of cardiac noradrenaline in animals; hypothesis-generating and requires human validation before clinical consideration.
The findings confirm that angiotensin II generated locally from precursor angiotensin I within cardiac and vascular tissues can modulate noradrenergic transmitter release.
Ziogas et al. (1984) studied this question.
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