September 1, 1984British Journal of PharmacologyOpen Access

Lack of a causal relationship between the vasodilator effect of papaverine and cyclic AMP production in the dog basilar artery

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Population

Smooth muscle cells of dog and guinea-pig basilar arteries

Design

Preclinical

Authors

MFMasahiko Fujioka

Discussion

Member takes

Implication

Challenges cAMP mediation of papaverine vasodilation; leaves open Ca2+ inhibition as primary mechanism for further study.

Structured PICO

Population

Smooth muscle cells of dog and guinea-pig basilar arteries

Intervention

Papaverine (up to 100 microM) and isoprenaline (up to 10 microM)

Outcome

Cyclic AMP production, membrane potential, membrane resistance, action potential, and contractionssurrogate

The vasodilator action of papaverine on the dog basilar artery is primarily mediated by inhibition of calcium influx and release, rather than through increased cyclic AMP levels.

Cite This Study

Masahiko Fujioka (1984) studied this question.

synapsesocial.com/papers/6a917f2c963a1f481f33fb0b https://doi.org/10.1111/j.1476-5381.1984.tb10125.x

View Full Paper

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Bookmark

Lack of a causal relationship between the vasodilator effect of papaverine and cyclic AMP production in the dog basilar artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lack of a causal relationship between the vasodilator effect of papaverine and cyclic AMP production in the dog basilar artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider