Population
Freshly isolated rabbit ear artery and portal vein cells
Comparison
Papaverine (10^-5 to 10^-3 M) vs Control conditions (noradrenaline alone)
Design
Preclinical
Authors
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Cautions against extrapolating rabbit cell findings to patients; leaves open mechanistic validation in human vessels.
Papaverine modulates noradrenaline-induced membrane currents in rabbit vascular smooth muscle cells by releasing and depleting caffeine-sensitive intracellular Ca2+ stores.
Wang et al. (1991) studied this question.
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