ANP has a physiological role in regulating circulatory blood volume distinct from that of NO, despite both increasing intracellular cGMP.
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Animal data differentiate ANP from NO effects on hematocrit; leaves open human volume-regulation relevance.
Sodium nitroprusside, nitroglycerin and carperitide (alpha-human ANP) all reduced mean blood pressure, but only carperitide increased the hematocrit in rats with bilateral renal artery- and ureter-ligation. NG-Monomethyl-L-arginine, a selective inhibitor of nitric oxide synthesis, elevated the mean blood pressure but did not change the hematocrit significantly. These findings suggest that ANP has a physiological role in regulating circulatory blood volume distinct from that of NO, although both increase intracellular cyclic GMP in the vasculature.
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Aisaka et al. (1992) studied this question.
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