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The asymmetric synthesis of 1-substituted 2,2,2-trifluoroethylamines from chiral 1,3-oxazolidines having trifluoromethyl group derived from trifluoromethyl ketones and (R)-phenylglycinol is described. The stereospecific reduction of chiral 1,3-oxazolidines with LiAlH4 proceeds in retention fashion.
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Ishii et al. (1998) studied this question.
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