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Case report demonstrates decade-long kidney allograft survival without maintenance immunosuppression in a transplant recipient, suggesting potential pathways to operational tolerance.
Operational tolerance of an allograft kidney is the optimal condition in patients following kidney transplantation and recipient‑mediated immunological rejection still remains the primary challenge following transplantation. In the present study, a case of long‑term survival is reported in a patient following kidney transplantation without maintenance immunosuppression therapies for >10 years. Although the pathological conditions of the transplanted kidney revealed a degree of impaired kidney function, the patient exhibited a serum creatinine level of 119.2 µmol/l and no significant changes were observed in T or B cell biomarkers associated with immunologic tolerance. Notably, the patient's allograft was functioning normally. Consequently, further studies may need to elucidate the development of operational tolerance.
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Feng et al. (2018) studied this question.
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