What question did this study set out to answer?

To identify noninvasive peripheral blood gene expression profiles and molecular pathways associated with operational tolerance in kidney graft recipients.

October 1, 2007Journal of Cellular Biochemistry

Immunosuppressive drug‐free operational immune tolerance in human kidney transplant recipients: Part I. blood gene expression statistical analysis

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Authors

CBChristophe Braud DBDominique Baeten MGMagali Giral

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Overview

Gene expression study reveals a 343-gene blood biomarker signature for operational tolerance in kidney transplant recipients, indicating a noninvasive strategy to guide immunosuppression tapering.

Key Points

To identify noninvasive peripheral blood gene expression profiles and molecular pathways associated with operational tolerance in kidney graft recipients.
Analyzed peripheral blood mononuclear cell (PBMC) gene expression profiles using high-throughput microarrays in kidney transplant recipients with operational tolerance, recipients with chronic rejection, and healthy volunteers.
Identified differentially expressed immune and defense genes and tested classification performance using cross-validation over time.
Identified a signature of 343 differentially expressed genes (mostly immune and defense related) between tolerant patients and patients with chronic rejection, with 223 genes also differing from healthy volunteers.
Correctly classified >80% of patients in cross-validation experiments and accurately classified 100% of samples evaluated longitudinally over time.

Cite This Study

Braud et al. (2007) studied this question.

synapsesocial.com/papers/6aa85148a789130cf6269f37 https://doi.org/10.1002/jcb.21574

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October 1, 2007Journal of Cellular Biochemistry

Immunosuppressive drug‐free operational immune tolerance in human kidney transplant recipients: Part I. blood gene expression statistical analysis

View Full Paper

Ask AI

Bookmark

Authors

CBChristophe Braud DBDominique Baeten MGMagali Giral

Discussion

Member takes

Overview

Gene expression study reveals a 343-gene blood biomarker signature for operational tolerance in kidney transplant recipients, indicating a noninvasive strategy to guide immunosuppression tapering.

Key Points

To identify noninvasive peripheral blood gene expression profiles and molecular pathways associated with operational tolerance in kidney graft recipients.
Analyzed peripheral blood mononuclear cell (PBMC) gene expression profiles using high-throughput microarrays in kidney transplant recipients with operational tolerance, recipients with chronic rejection, and healthy volunteers.
Identified differentially expressed immune and defense genes and tested classification performance using cross-validation over time.
Identified a signature of 343 differentially expressed genes (mostly immune and defense related) between tolerant patients and patients with chronic rejection, with 223 genes also differing from healthy volunteers.
Correctly classified >80% of patients in cross-validation experiments and accurately classified 100% of samples evaluated longitudinally over time.

Cite This Study

Braud et al. (2007) studied this question.

synapsesocial.com/papers/6aa85148a789130cf6269f37 https://doi.org/10.1002/jcb.21574

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