Key result
Tolerance induction by anti-CD80 and anti-CD86 mAbs in murine cardiac allografts was associated with marked expression of pro-inflammatory and apoptosis-related genes maintained >70 days posttransplant.
Why the study?
Does daily intraperitoneal injection of anti-CD80 and anti-CD86 mAbs alter gene expression profiles in a murine cardiac allograft model?
Population
Murine cardiac allograft model (BALB/c to C57BL/6 mice)
Comparison
Daily intraperitoneal injection of anti-CD80 and… vs Syngeneic isografts and rejecting allografts
Design
Preclinical
Follow-up
more than 70 days posttransplant
Authors
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Hypothesis-generating for tolerance despite inflammation in allografts; should not yet influence clinical immunosuppression protocols.
Does daily intraperitoneal injection of anti-CD80 and anti-CD86 mAbs alter gene expression profiles in a murine cardiac allograft model?
Immunologic tolerance in murine cardiac allografts can be induced and maintained despite prominent pro-inflammatory gene expression.
Matsui et al. (2003) studied Cardiac allograft tolerance. anti-CD80 and anti-CD86 monoclonal antibodies vs. syngeneic isografts and rejecting allografts was evaluated on Global gene expression analysis. Tolerance induction by anti-CD80 and anti-CD86 mAbs in murine cardiac allografts was associated with marked expression of pro-inflammatory and apoptosis-related genes maintained >70 days posttransplant.
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