Key result
Inherited cardiovascular risk testing and family history assessment offer opportunities to improve coronary heart disease risk prediction and treatment selection, despite barriers to clinical adoption.
Highlights the importance of utilizing family history and genetic testing for CHD risk prediction and calls for overcoming barriers to clinical adoption.
May refine CHD risk stratification clinically; leaves open validation and barrier resolution in prospective studies.
A family history of coronary heart disease (CHD) is an accepted risk factor for cardiovascular events and is independent of common CHD risk factors. Advances in the understanding of genetic influences on CHD risk provide the opportunity to apply this knowledge and improve patient care. Utility of inherited cardiovascular risk testing exists by utilizing both phenotypes and genotypes and includes improved CHD risk prediction, selection of the most appropriate treatment, prediction of outcome, and family counseling. The major impediment to widespread clinical adoption of this concept involves un‐reimbursed staff time, educational needs, access to a standardized and efficient assessment mechanism, and privacy issues. The link between CHD and inheritance is indisputable and the evidence strong and consistent. For clinicians, the question is how to utilize this information, in an efficient manner, in order to improve patient care and detection of high‐risk family members.
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Superko et al. (2010) conducted a review in Coronary heart disease. Inherited cardiovascular risk testing was evaluated. Inherited cardiovascular risk testing and family history assessment offer opportunities to improve coronary heart disease risk prediction and treatment selection, despite barriers to clinical adoption.
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