Elevated Serum Iron Levels and Persistent Australia Antigen (HBSAg)

Letters1 December 1974Elevated Serum Iron Levels and Persistent Australia Antigen (HBSAg)ALTON I. SUTNICK, M.D., F.A.C.P., BARUCH S. BLUMBERG, M.D., D. PHIL., F.A.C.P., EDWARD D. LUSTBADER, PH.D.ALTON I. SUTNICK, M.D., F.A.C.P.Search for more papers by this author, BARUCH S. BLUMBERG, M.D., D. PHIL., F.A.C.P.Search for more papers by this author, EDWARD D. LUSTBADER, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-6-855 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Kolk-Vegter, Bosch, and van Leeuwen (1) described 11 patients with chronic renal disease treated at a hemodialysis unit in Amsterdam, The Netherlands. They developed anicteric hepatitis, with serum glutamic pyruvic transaminase (SGPT) elevations of over 150 units. In all but one, Australia antigen (hepatitis B surface antigen, HBSAg) was detected in the blood. All the patients had a spontaneous rise in hemoglobin level, and transfusion requirements were less than those of 34 other dialysis patients who did not have liver disease.In 1965 we began evaluating patients with Down's syndrome and HBSAg and in 1966 found that...References1. KOLK-VEGTER A, BOSCH E, and VAN LEEUWEN A: Influence of serum hepatitis on haemoglobin level in patients on regular haemodialysis. Lancet 1:526-528, 1971 CrossrefMedlineGoogle Scholar2. BLUMBERG B, GERSTLEY B, and HUNGERFORD D: A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis. Ann Intern Med 66:924-931, 1967 LinkGoogle Scholar3. SUTNICK A, LONDON W, and BLUMBERG B: Persistent anicteric hepatitis with Australia antigen in patients with Down's syndrome. Am J Clin Pathol 57:2-12, 1972 CrossrefMedlineGoogle Scholar4. DUCCI H, SPOERER A, and KATZ R: Serum iron in liver disease. Gastroenterology 22:52-63, 1952 CrossrefMedlineGoogle Scholar5. PETERS T, GIOVANNIELLO T, and APT L: A simple improved method for the determination of serum iron. II. J Lab Clin Med 48:280-288, 1956 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALTON I. SUTNICK, M.D., F.A.C.P.; BARUCH S. BLUMBERG, M.D., D. PHIL., F.A.C.P.; EDWARD D. LUSTBADER, PH.D.Affiliations: The Institute for Cancer Research Fox Chase Cancer Center Philadelphia, Pennsylvania 19111*This work was supported by U.S. Public Health Service grants CA-06551, CA-06927, and RR-05539 and by an appropriation from the Commonwealth of Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRelationship between iron overload caused by abnormal hepcidin expression and liver disease: A reviewThe role of iron in hepatic inflammation and hepatocellular carcinomaImprovement of chronic hepatitis B by iron chelation therapy in a patient with iron overloadProtein alteration of HepG2.2.15 cells induced by iron overloadViruses and Cancer: A Historical Perspective – HBV and Prevention of a CancerHepatitis BLiver iron deposits in hepatitis B patients: Association with severity of liver disease but not with hemochromatosis gene mutations22 Hepatitis C and ironAvailable options for treatment of interferon nonrespondersRelationship between the serum alanine aminotransferase level at the end of interferon treatment and histologic changes in wild-type and precore mutant hepatitis B virus infectionsHepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis CLiver transplantation for hepatitis B virus—associated cirrhosis: A progress reportIntracellular IronResponse to interferon α therapy is influenced by the iron content of the liverHepatitis B virus infection markers in genetic haemochromatosisIncreased serum ferritin in chronic liver disease: A risk factor for primary hepatocellular carcinomaIron, ferritin, hepatitis B surface and core antigens in the livers of chinese patients with hepatocellular carcinoma`Hepatitis B Virus, Iron and Iron-Binding ProteinsLiver iron stores and hepatitis B antigen statusSerum Ferritin as a Predictor of Host Response to Hepatitis B Virus InfectionTrace Elements in Infectious Processes 1 December 1974Volume 81, Issue 6Page: 855-856KeywordsAntigensDown syndromeHemoglobinHepatitisHepatitis B surface antigenLiver diseasesMedical dialysisMedical servicesRenal diseasesSerum glutamic pyruvic transaminase ePublished: 1 December 2008 Issue Published: 1 December 1974 PDF downloadLoading ...