Key result
Single nucleotide polymorphisms of platelet receptors GPIa, GPVI, and P2Y12 were not significantly associated with an increased risk of periprocedural bleeding in patients undergoing CAG or PCI.
Why the study?
Are single nucleotide polymorphisms of platelet receptors GPIa, GPVI, and P2Y12 associated with an increased risk of periprocedural bleeding in patients undergoing CAG/PCI?
Case-Control (n=404)
Yes
Are single nucleotide polymorphisms of platelet receptors GPIa, GPVI, and P2Y12 associated with an increased risk of periprocedural bleeding in patients undergoing CAG/PCI?
Odds Ratio: 1.29 (95% CI 0.75–2.24)
p-value: p=0.334
Genetic variations in crucial haemostatic platelet receptors (GPIa, GPVI, P2Y12) do not appear to significantly increase the risk of periprocedural bleeding in patients undergoing CAG/PCI.
No association seen in this case-control study; leaves open whether these SNPs warrant testing to guide periprocedural antithrombotic strategies in PCI.
INTRODUCTION: Periprocedural bleeding related to coronary angiography (CAG) or percutaneous coronary intervention (PCI) is associated with worse prognosis. Determining genetic variations associated with increased bleeding risk may help to identify high-risk patients. AIM: To analyse the association between single nucleotide polymorphisms (SNPs) of crucial haemostatic platelet receptors (GPIa, GPVI, P2Y12) and the risk of periprocedural bleeding complications related to CAG/PCI. MATERIAL AND METHODS: The population consisted of 73 patients with ischaemic heart disease who developed bleeding complications within 30 days after CAG/PCI and 331 patients without bleeding. The frequency of SNPs of GPIa 807C/T, GPVI 13254T/C, P2Y12 32C/T, and P2Y12 H1/H2 haplotype was analysed using polymerase chain reaction (PCR) hybridization methods. RESULTS: = 0.161). CONCLUSIONS: No significant association of the SNPs of GPIa 807C/T, GPVI 13254T/C, P2Y12 32C/T, and P2Y12 H1/H2 haplotype with increased risk of periprocedural bleeding was found in patients with ischaemic heart disease undergoing CAG/PCI.
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Sionová et al. (2017) conducted a case-control in Ischaemic heart disease (n=404). Single nucleotide polymorphisms of platelet receptors (GPIa, GPVI, P2Y12) vs. Wild-type alleles was evaluated on Periprocedural bleeding complications within 30 days (OR 1.29, 95% CI 0.75-2.24, p=0.334). Single nucleotide polymorphisms of platelet receptors GPIa, GPVI, and P2Y12 were not significantly associated with an increased risk of periprocedural bleeding in patients undergoing CAG or PCI.
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