What is the clinical evidence from this study?

Study design: Case-Control. Population: Pre-eclampsia and gestational hypertension (n=871). Intervention: Prothrombotic gene polymorphisms vs. Control women. Primary outcome: Pre-eclampsia and gestational hypertension.

January 1, 2002Thrombosis and Haemostasis

Prothrombotic Genotypes Are not Associated with Pre-eclampsia and Gestational Hypertension: Results from a Large Population-based Study and Systematic Review

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Key result

In a study of 871 women, five prothrombotic gene polymorphisms were not significantly associated with the development of pre-eclampsia or gestational hypertension.

Why the study?

Are prothrombotic gene polymorphisms associated with the development of pre-eclampsia or gestational hypertension in women?

Population

871 women from a large population-based case-control study

Comparison

Presence of five prothrombotic gene polymorphisms vs Control women without pre-eclampsia or…

Design

Case-control

Authors

EME. R. MorrisonUniversity of Aberdeen DCD. M. CampbellUniversity of Connecticut NHN E HaitesUniversity of Aberdeen

Discussion

Member takes

Implication

Does not support antenatal screening for these polymorphisms; leaves open confirmation in larger prospective cohorts.

Study Design

Type

Case-Control (n=871)

Structured PICO

Are prothrombotic gene polymorphisms associated with the development of pre-eclampsia or gestational hypertension in women?

Population

871 women, comprising 404 with pre-eclampsia, 303 with gestational hypertension, and 164 controls, evaluated for prothrombotic gene polymorphisms.

Exposure

Presence of five prothrombotic gene polymorphisms (Factor V Leiden G1691A, prothrombin G20210A, MTHFR C677T, PAI-1 4G/5G, platelet collagen receptor alpha2beta1 C807T)

Comparator

Control women without pre-eclampsia or gestational hypertension

Outcome

Frequency of prothrombotic genotypes in women with pre-eclampsia or gestational hypertension compared to controls

Prothrombotic genotypes are not associated with the development of pre-eclampsia or gestational hypertension, suggesting little value in antenatal screening for these polymorphisms.

Cite This Study

Morrison et al. (2002) conducted a case-control in Pre-eclampsia and gestational hypertension (n=871). Prothrombotic gene polymorphisms vs. Control women was evaluated on Pre-eclampsia and gestational hypertension. In a study of 871 women, five prothrombotic gene polymorphisms were not significantly associated with the development of pre-eclampsia or gestational hypertension.

synapsesocial.com/papers/6a918b7073240bb033f07547 https://doi.org/10.1055/s-0037-1613083

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January 1, 2002Thrombosis and Haemostasis

Prothrombotic Genotypes Are not Associated with Pre-eclampsia and Gestational Hypertension: Results from a Large Population-based Study and Systematic Review

View Full Paper

Ask AI

Bookmark

Key result

In a study of 871 women, five prothrombotic gene polymorphisms were not significantly associated with the development of pre-eclampsia or gestational hypertension.

Why the study?

Are prothrombotic gene polymorphisms associated with the development of pre-eclampsia or gestational hypertension in women?

Population

871 women from a large population-based case-control study

Comparison

Presence of five prothrombotic gene polymorphisms vs Control women without pre-eclampsia or…

Design

Case-control

Authors

EME. R. MorrisonUniversity of Aberdeen DCD. M. CampbellUniversity of Connecticut NHN E HaitesUniversity of Aberdeen

Discussion

Member takes

Implication

Does not support antenatal screening for these polymorphisms; leaves open confirmation in larger prospective cohorts.

Study Design

Type

Case-Control (n=871)

Structured PICO

Are prothrombotic gene polymorphisms associated with the development of pre-eclampsia or gestational hypertension in women?

Population

871 women, comprising 404 with pre-eclampsia, 303 with gestational hypertension, and 164 controls, evaluated for prothrombotic gene polymorphisms.

Exposure

Presence of five prothrombotic gene polymorphisms (Factor V Leiden G1691A, prothrombin G20210A, MTHFR C677T, PAI-1 4G/5G, platelet collagen receptor alpha2beta1 C807T)

Comparator

Control women without pre-eclampsia or gestational hypertension

Outcome

Frequency of prothrombotic genotypes in women with pre-eclampsia or gestational hypertension compared to controls

Prothrombotic genotypes are not associated with the development of pre-eclampsia or gestational hypertension, suggesting little value in antenatal screening for these polymorphisms.

Cite This Study

synapsesocial.com/papers/6a918b7073240bb033f07547 https://doi.org/10.1055/s-0037-1613083

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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