Key result
Prothrombin gene heterozygous AG genotype was significantly more frequent in preeclampsic patients than controls (20.7% vs 4.0%; OR 6.2, P=0.006), as was Factor V Leiden AG genotype (8.7% vs 0%).
Why the study?
Does Factor V Leiden and Prothrombin gene polymorphism increase the risk of preeclampsia in pregnant women?
Case-Control (n=142)
Does Factor V Leiden and Prothrombin gene polymorphism increase the risk of preeclampsia in pregnant women?
Odds Ratio: 6.2
Absolute Event Rate: 20.7% vs 4%
p-value: p=0.006
Prothrombin gene and Factor V Leiden polymorphisms are significantly associated with an increased risk of preeclampsia.
These polymorphisms were associated with preeclampsia; hypothesis-generating and requires prospective validation before clinical adoption.
Objective: To identify polymorphism of Factor V Leiden and Prothrombin gene in women suffering from preeclampsia. Study design: From 142 pregnant women we identified 92 women suffering from preeclampsia and 50 healthy controls with normal pregnancy matched for age and socioeconomic status, preeclampsic patient classified as mild preeclampsia 42(45.7%) and severe preeclampsia 50(54.3%). Blood samples were tested for DNA polymorphism affecting thrombophilia Factor V Leiden and Prothrombin gene polymorphism. Results: Heterozygous AG genotype showed a significant high frequency among preeclampsic patients (20.7%) compared to controls (4.0%), (OR 6.2, P= 0.006) regarding to Prothrombin gene but: Factor V Leiden, AG genotype showed (8.7%) of preeclampsic patients which was absent in any of the controls.
No takes yet. Share an insight, caveat, or question.
Baz et al. (2014) conducted a case-control in Preeclampsia (n=142). Factor V Leiden and Prothrombin gene polymorphism vs. Healthy controls with normal pregnancy was evaluated on Heterozygous AG genotype of Prothrombin gene (OR 6.2, p=0.006). Prothrombin gene heterozygous AG genotype was significantly more frequent in preeclampsic patients than controls (20.7% vs 4.0%; OR 6.2, P=0.006), as was Factor V Leiden AG genotype (8.7% vs 0%).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: