Key result
Factor V Leiden and thrombomodulin gene variants showed no association with pre-eclampsia in homogenous Zulu speaking South African women.
Why the study?
Are Factor V Leiden and thrombomodulin gene variants associated with pre-eclampsia in Black Zulu speaking South African women?
Case-Control (n=210)
Are Factor V Leiden and thrombomodulin gene variants associated with pre-eclampsia in Black Zulu speaking South African women?
Factor V Leiden and thrombomodulin gene variants do not appear to contribute to the vascular endothelial dysfunction of pre-eclampsia in Black Zulu speaking South African women.
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No association in Zulu women; leaves open ancestry-specific genetic contributions to pre-eclampsia and does not support testing.
Hira et al. (2003) conducted a case-control in Pre-eclampsia (n=210). Factor V Leiden and thrombomodulin gene variants vs. Absence of variants was evaluated on Association with pre-eclampsia. Factor V Leiden and thrombomodulin gene variants showed no association with pre-eclampsia in homogenous Zulu speaking South African women.
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