Key result
First-dose chemotherapeutic agents in children frequently caused acute conduction disturbances and arrhythmias, but no life-threatening events or adverse consequences were observed.
Why the study?
Do first-dose chemotherapeutic agents cause acute arrhythmias in children with malignancies?
Population
33 children with diverse malignancies
Comparison
First-dose chemotherapeutic agents vs Baseline (24 hours before therapy)
Design
Cohort
Follow-up
24 hours following first-dose therapy
Authors
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First-dose chemo was associated with non-life-threatening arrhythmias in children; leaves open whether monitoring protocols warrant adjustment pending prospective confirmation.
Cohort (n=33)
Do first-dose chemotherapeutic agents cause acute arrhythmias in children with malignancies?
First-dose chemotherapeutic agents frequently cause non-life-threatening conduction disturbances and arrhythmias in children, but these do not appear to have acute or long-term adverse consequences.
Massin et al. (2002) conducted a cohort in Diverse malignancies (n=33). First-dose chemotherapeutic agents vs. Baseline (24 hours before therapy) was evaluated on Acute arrhythmogenicity (conduction disturbances and arrhythmias). First-dose chemotherapeutic agents in children frequently caused acute conduction disturbances and arrhythmias, but no life-threatening events or adverse consequences were observed.
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