Why the study?
Does sodium nitroprusside compared to trimethaphan increase operative blood loss during induced hypotension in young healthy patients undergoing mandibular osteotomies?
Population
20 young healthy patients scheduled for bilateral sagittal osteotomies of the mandible.
Comparison
Sodium nitroprusside infused to maintain mean… vs Trimethaphan infused to maintain mean arterial…
Follow-up
intraoperative
Authors
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MAP, not cardiac output, drives blood loss during induced hypotension; leaves open agent effects in broader or higher-risk populations.
Does sodium nitroprusside compared to trimethaphan increase operative blood loss during induced hypotension in young healthy patients undergoing mandibular osteotomies?
Operative blood loss during induced hypotension is determined by mean arterial pressure rather than cardiac output.
SILVARAJAN et al. (1981) studied this question.
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