Why the study?
Does sodium nitroprusside compared to trimethaphan increase blood loss during induced hypotension in young healthy patients?
Population
20 young healthy patients scheduled for bilateral sagittal osteotomies of the mandible.
Comparison
Sodium nitroprusside infused to maintain mean… vs Trimethaphan infused to maintain mean arterial…
Design
Other
Follow-up
intraoperative
Authors
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Supports MAP over cardiac output as determinant of blood loss; leaves open agent selection in contemporary practice.
Does sodium nitroprusside compared to trimethaphan increase blood loss during induced hypotension in young healthy patients?
Operative blood loss during induced hypotension is determined by mean arterial pressure rather than cardiac output.
Sivarajan et al. (1980) studied this question.
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