Key result
Trimethaphan produced higher spinal cord perfusion pressure (P<0.005) and better neurologic outcomes (P<0.05) compared to sodium nitroprusside in dogs undergoing thoracic aortic cross-clamping.
Why the study?
Does trimethaphan improve neurologic outcome compared to sodium nitroprusside in a dog model of thoracic aortic cross-clamping?
Population
16 mongrel dogs undergoing descending thoracic aortic cross-clamping (TACC) for 45 min
Comparison
Trimethaphan to maintain mean proximal aortic… vs Sodium nitroprusside to maintain mean proximal…
Design
Preclinical, blinded observer for neurologic evaluation
Follow-up
48 hours
Authors
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Should not change practice in aortic surgery; leaves open translation of neuroprotection to human trials.
Does trimethaphan improve neurologic outcome compared to sodium nitroprusside in a dog model of thoracic aortic cross-clamping?
p-value: p=<0.05
In a canine model of thoracic aortic cross-clamping, trimethaphan improved spinal cord perfusion pressure and neurologic outcomes compared to sodium nitroprusside.
Simpson et al. (1996) studied Proximal hypertension during thoracic aortic cross-clamping (n=16). Trimethaphan vs. Sodium nitroprusside (SNP) was evaluated on Neurologic outcome assessed by Tarlov's score at 24 and 48 h (p=<0.05). Trimethaphan produced higher spinal cord perfusion pressure (P<0.005) and better neurologic outcomes (P<0.05) compared to sodium nitroprusside in dogs undergoing thoracic aortic cross-clamping.
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