What is the clinical evidence from this study?

Study design: RCT. Population: Acute myocardial infarction (n=35). Intervention: Glucose-insulin-potassium (GIK) vs. Placebo (normal saline). Primary outcome: Plasma levels of lipid peroxidation (malondialdehyde), superoxide dismutase, glutathione peroxidase, and catalase erythrocyte activities.

February 1, 2002Critical Care Medicine

Oxidative stress after reperfusion with primary coronary angioplasty: Lack of effect of glucose-insulin-potassium infusion

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Key result

Glucose-insulin-potassium infusion did not significantly improve oxidative stress markers or enzymatic antioxidant reserve compared to placebo in patients with acute myocardial infarction.

Why the study?

Does glucose-insulin-potassium infusion improve oxidative stress status in patients with acute myocardial infarction undergoing primary angioplasty?

Study Design

Type

RCT (n=35)

Blinding

Double-blind

Randomization

randomized

Multicenter

Structured PICO

Does glucose-insulin-potassium infusion improve oxidative stress status in patients with acute myocardial infarction undergoing primary angioplasty?

Population

20 patients with acute myocardial infarction undergoing primary angioplasty randomized to GIK or placebo, compared with 15 healthy volunteers.

Intervention

Glucose-insulin-potassium (GIK) solution (30% glucose in water with insulin 50 IU/L, and KCl 40 mM) at 1.5 mL/kg/hr for 24 hrs.

Comparator

Placebo (normal saline) at 1.5 mL/kg/hr for 24 hrs.

Outcome

Plasma levels of lipid peroxidation estimated by the malondialdehyde assay, superoxide dismutase, glutathione peroxidase, and catalase erythrocyte activities at admission and 0.5 and 24 hrs after angioplasty.surrogate

Glucose-insulin-potassium infusion does not improve the increased oxidative stress and reduced antioxidant reserve observed in patients with acute myocardial infarction undergoing primary angioplasty.

Discussion

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Implication

GIK offers no oxidative stress benefit in AMI; confirms neutral effects on antioxidant markers and discourages further trials targeting this pathway.

Cite This Study

Dı́az-Araya et al. (2002) conducted an RCT in Acute myocardial infarction (n=35). Glucose-insulin-potassium (GIK) vs. Placebo (normal saline) was evaluated on Plasma levels of lipid peroxidation (malondialdehyde), superoxide dismutase, glutathione peroxidase, and catalase erythrocyte activities. Glucose-insulin-potassium infusion did not significantly improve oxidative stress markers or enzymatic antioxidant reserve compared to placebo in patients with acute myocardial infarction.

synapsesocial.com/papers/6a918f029732cc92acd2dc7e https://doi.org/10.1097/00003246-200202000-00025

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Implication

GIK offers no oxidative stress benefit in AMI; confirms neutral effects on antioxidant markers and discourages further trials targeting this pathway.

Oxidative stress after reperfusion with primary coronary angioplasty: Lack of effect of glucose-insulin-potassium infusion

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Oxidative stress after reperfusion with primary coronary angioplasty: Lack of effect of glucose-insulin-potassium infusion

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider