Key result
Plasmapheresis reduces severe hypertriglyceridemia by ~95% in acute pancreatitis.
Why the study?
Severe hypertriglyceridemia presenting as acute pancreatitis in the setting of diabetic ketoacidosis is a rare combination.
Case Report (n=1)
No
Plasmapheresis combined with insulin infusion can be a lifesaving therapeutic option for severe hypertriglyceridemia-induced acute pancreatitis complicated by diabetic ketoacidosis.
Severe hypertriglyceridemia (HTG) presenting as acute pancreatitis (AP) in the setting of diabetic ketoacidosis (DKA) is a rare combination, reported as the enigmatic triad in literature. Here we present a case of a 26-year-old woman, with diabetes mellitus (DM) for three years, who presented with features suggestive of acute pancreatitis complicated with DKA in addition to systemic inflammatory response syndrome (SIRS) and acute respiratory distress syndrome (ARDS). Evaluation revealed severe HTG to the tune of 9947 mg/dL. She was managed with insulin infusion combined with three sessions of plasmapheresis, which led to marked clinical and biochemical improvement. This case highlights the importance of plasmapheresis as a lifesaving therapeutic option for severe HTG-induced AP.
No takes yet. Share an insight, caveat, or question.
Neduvancheri et al. (2025) conducted a case report in Severe hypertriglyceridemia-induced acute pancreatitis (n=1). Plasmapheresis was evaluated on Triglyceride levels. Three sessions of plasmapheresis successfully reduced severe hypertriglyceridemia from 9947 mg/dL to 484 mg/dL, leading to marked clinical improvement in a patient with acute pancreatitis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: