Key result
Intravenous insulin did not significantly accelerate triglyceride reduction compared to conservative management (85% vs 79% decrease by day 4) in hypertriglyceridemia-associated acute pancreatitis.
Why the study?
Intravenous insulin is assumed to lower triglycerides in hypertriglyceridemia-associated acute pancreatitis, but its efficacy compared to conservative management alone is not known.
Does intravenous insulin improve triglyceride lowering compared to conservative management in patients with hypertriglyceridemia-associated acute pancreatitis?
Population
106 patients admitted with HAAP and triglyceride concentrations >1000 mg/dL at admission
Comparison
Intravenous insulin for at least 8 hours vs conservative management
Design
Retrospective chart review
Authors
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IV insulin adds no TG-lowering benefit beyond fasting and fluids in HAAP; leaves open whether randomized trials would alter this observational finding.
Cohort (n=106)
Does intravenous insulin improve triglyceride lowering compared to conservative management in patients with hypertriglyceridemia-associated acute pancreatitis?
Absolute Event Rate: 85% vs 79%
Intravenous insulin does not provide additional benefit over conservative management (fasting and IV fluids) for rapidly lowering triglycerides in hypertriglyceridemia-associated acute pancreatitis.
Dhindsa et al. (2019) conducted a cohort in Hypertriglyceridemia-associated acute pancreatitis (n=106). Intravenous insulin vs. Conservative management was evaluated on Change in triglyceride concentrations from baseline. Intravenous insulin did not significantly accelerate triglyceride reduction compared to conservative management (85% vs 79% decrease by day 4) in hypertriglyceridemia-associated acute pancreatitis.
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