Key result
High resting serum creatine kinase was associated with failure of antihypertensive treatment compared to the lowest tertile (72.9% vs 46.7%; adjusted OR 3.7, 95% CI 1.2-10.9).
Why the study?
Is high resting serum creatine kinase associated with failure of antihypertensive treatment in the general population?
Population
1,444 adults aged 34-60 years from a cross-sectional, random multiethnic sample of the general population
Comparison
High resting serum creatine kinase vs Low resting serum creatine kinase
Design
Cross-sectional
Authors
Loading...
Should not yet change practice; hypothesis-generating for CK as marker of treatment-resistant hypertension.
Cross-Sectional (n=1,444)
Is high resting serum creatine kinase associated with failure of antihypertensive treatment in the general population?
Odds Ratio: 3.7 (95% CI 1.2–10.9)
Absolute Event Rate: 72.9% vs 46.7%
p-value: p=0.004
High resting serum creatine kinase is independently associated with failure of antihypertensive therapy, suggesting a potential novel mechanism or marker for difficult-to-treat hypertension.
Oudman et al. (2013) conducted a cross-sectional in Hypertension (n=1,444). High resting serum creatine kinase (>145 IU/l) vs. Low resting serum creatine kinase (<88 IU/l) was evaluated on Treated uncontrolled hypertension (treatment failure) (adjusted OR 3.7, 95% CI 1.2-10.9, p=0.004). High resting serum creatine kinase was associated with failure of antihypertensive treatment compared to the lowest tertile (72.9% vs 46.7%; adjusted OR 3.7, 95% CI 1.2-10.9).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: