Why the study?
Does doxapram infusion improve postoperative oxygenation or reduce chest infections in grossly obese patients who have undergone upper abdominal surgery?
Does doxapram infusion improve postoperative oxygenation or reduce chest infections in grossly obese patients who have undergone upper abdominal surgery?
Doxapram infusion does not significantly improve postoperative oxygenation or reduce chest infections in obese patients undergoing upper abdominal surgery.
No support for doxapram to reduce hypoxaemia or infections; leaves open need for adequately powered trials in obese surgical patients.
A infusion of doxapram in 5% dextrose at a rate of 2 mg/kg/hour for 6 hours, or of 5% dextrose alone, was given to 20 grossly obese patients who had undergone upper abdominal surgery. There was no statistically significant difference in the degree of hypoxaemia or the incidence of chest infections between the two groups.
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HOLLWAY et al. (1982) studied this question.
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