Key result
The G allele of rs2279885 and the C allele of rs2271072 in the FABP3 gene were significantly more frequent in Japanese patients with essential hypertension than in normotensive controls (P=0.0339 and P=0.0209).
Why the study?
Are FABP3 gene variants associated with essential hypertension in humans?
Case-Control (n=1,484)
Are FABP3 gene variants associated with essential hypertension in humans?
p-value: p=0.0339 and 0.0209
FABP3 gene polymorphisms (rs2279885 and rs2271072) are associated with essential hypertension in a Japanese population, suggesting it as a susceptibility locus.
FABP3 variants were associated with essential hypertension in this Japanese case-control study; hypothesis-generating and should not yet inform clinical risk assessment.
BACKGROUND: We have earlier identified a quantitative trait locus (QTL) on rat chromosome 5 that appears to be primarily under the control of the sympathetic nervous system. Because sympathetic overactivity is related to both hypertension and insulin resistance, FABP3 is a candidate gene for the link between this QTL and blood pressure regulation. In this study, therefore, we explored the role of FABP3 genetic variations in essential hypertension (EH) in humans. METHODS: We evaluated two single-nucleotide polymorphisms (SNPs) (rs2279885 and rs2271072) in 758 patients with EH and 726 controls. Polymorphism-related genotypes were determined using TaqMan assays, while haplotypes were estimated from the genotype data. RESULTS: The frequencies of occurrence of the G allele of rs2279885 and the C allele of rs2271072 were significantly higher in subjects with EH than in normotensive (NT) subjects (P = 0.0339, P = 0.0209, respectively). However, the genotype distributions did not exhibit any significant differences. CONCLUSION: We found an association between FABP3 gene polymorphisms and EH in a Japanese population, thereby suggesting that FABP3 is a susceptibility locus for EH.
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Ueno et al. (2008) conducted a case-control in Essential hypertension (n=1,484). FABP3 gene variants (rs2279885 and rs2271072) vs. Normotensive controls was evaluated on Allele frequencies of rs2279885 and rs2271072 (p=0.0339 and 0.0209). The G allele of rs2279885 and the C allele of rs2271072 in the FABP3 gene were significantly more frequent in Japanese patients with essential hypertension than in normotensive controls (P=0.0339 and P=0.0209).
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