July 1, 2003Journal of the American Society of Nephrology
Prevention of Hypertension and Its Complications
Key result
Lowering blood pressure with multidrug therapy including renin-angiotensin system modulators is an effective strategy to forestall progressive loss of kidney function in hypertensive patients.
Why the study?
Does blood pressure lowering with RAS modulators prevent CKD progression and reduce cardiovascular risk in hypertensive patients with CKD or diabetes?
Population
Hypertensive persons with reduced kidney function and/or proteinuria, and persons with diabetes mellitus and…
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
Supports RAS-inclusive BP lowering to slow CKD progression in hypertension; leaves open optimal targets and CV outcomes in diabetes pending RCTs.
Structured PICO
Does blood pressure lowering with RAS modulators prevent CKD progression and reduce cardiovascular risk in hypertensive patients with CKD or diabetes?
P
Population
Hypertensive persons with reduced kidney function and/or proteinuria, and persons with diabetes mellitus and CKD
I
Intervention
Blood pressure lowering with multidrug therapy including renin-angiotensin system (RAS) modulators (ACE inhibitors or ARBs)
O
Outcome
Prevention of CKD or forestalling its progression
Aggressive blood pressure control using RAS modulators is essential for preserving kidney function and reducing cardiovascular risk in patients with hypertension, CKD, and diabetes.
Cite This Study
Flack et al. (2003) conducted a review in Hypertension and Chronic Kidney Disease. Antihypertensive therapy (RAS modulators) was evaluated. Lowering blood pressure with multidrug therapy including renin-angiotensin system modulators is an effective strategy to forestall progressive loss of kidney function in hypertensive patients.