Why the study?
Does chronic hypoxia alter cardiovascular responsiveness to beta-adrenergic stimulation and blockade in conscious dogs?
Population
9 conscious dogs
Comparison
Exposure to chronic hypobaric hypoxia followed… vs Normoxia
Design
Preclinical
Follow-up
10 days
Authors
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Attenuated chronotropic response in hypoxic dogs suggests cardiac refractoriness; hypothesis-generating for human hypoxemia and requires clinical validation.
Does chronic hypoxia alter cardiovascular responsiveness to beta-adrenergic stimulation and blockade in conscious dogs?
Chronic hypobaric hypoxia attenuates the chronotropic response to beta-adrenoceptor stimulation, suggesting relative cardiac refractoriness secondary to increased sympathetic activity.
Maher et al. (1975) studied this question.
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