Key result
The rate of recovery from slow inactivation in voltage-gated potassium channels is determined by the identity of the trapped intracellular cation, following the rank order K+ > NH4+ > Rb+ > Cs+ >> Na+.
Population
Voltage-gated potassium channels
Comparison
Intracellular permeant cations vs Different cations compared to each other
Design
Preclinical
Authors
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No immediate clinical implications; extends mechanistic understanding of potassium channel slow inactivation for future research.
Demonstrates that recovery from slow inactivation in voltage-gated potassium channels is regulated by the identity of trapped intracellular cations moving into a binding site in the selectivity filter.
Ray et al. (2006) studied this question. Intracellular permeant cations was evaluated on Rate of recovery from slow inactivation. The rate of recovery from slow inactivation in voltage-gated potassium channels is determined by the identity of the trapped intracellular cation, following the rank order K+ > NH4+ > Rb+ > Cs+ >> Na+.
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