Key result
Levobupivacaine demonstrated similar onset time, duration of analgesia, and quality of motor blockade compared to bupivacaine for supraclavicular brachial plexus block.
Why the study?
Does levobupivacaine provide similar onset, duration, and quality of block compared to bupivacaine in patients undergoing elective forearm orthopaedic surgeries?
RCT (n=60)
Randomized
Does levobupivacaine provide similar onset, duration, and quality of block compared to bupivacaine in patients undergoing elective forearm orthopaedic surgeries?
Levobupivacaine provides a similar pharmacodynamic profile to bupivacaine for supraclavicular brachial plexus blocks, with the advantage of decreased cardiotoxicity.
Supports levobupivacaine as a safer alternative for supraclavicular blocks; confirms equivalent onset, duration, and motor quality versus bupivacaine.
BACKGROUND of upper limb are usually done under brachial plexus blockade of which supraclavicular approach is commonly used. , lignocaine, and ropivacaine are commonly used local anaesthetic agents. present study is a prospective observational study to evaluate the onset of sensory blockade, quality of motor blockade, of analgesia, and intraoperative side effects if any of bupivacaine and levobupivacaine in supraclavicular brachial blockade. Study was conducted in ASA grade 1 and 2 patients posted for elective forearm orthopaedic surgeries. A size of 60 patients were randomly allocated into two groups. Supraclavicular brachial plexus block was given using a nerve stimulator. received 30 mL of 0.375% local anaesthetic. One group received bupivacaine and another group levobupivacaine. Onset block, quality of motor block, duration of analgesia, and side effects of drugs were recorded and studied. Statistical analysis done. Test of significance such as t test for qualitative variables and chi-square test for quantitative variables were done. observed that the onset time, duration of analgesia, and quality of motor blockade of levobupivacaine were not significantly from those of bupivacaine. on this study, levobupivacaine can be recommended over bupivacaine for brachial plexus blocks because of its similar profile and decreased cardiotoxicity.
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Nadarajan et al. (2016) conducted an RCT in Forearm orthopaedic surgeries (n=60). Levobupivacaine vs. Bupivacaine was evaluated on Onset of block, quality of motor block, and duration of analgesia. Levobupivacaine demonstrated similar onset time, duration of analgesia, and quality of motor blockade compared to bupivacaine for supraclavicular brachial plexus block.
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