Key result
In patients treated with edoxaban, prothrombin time (PT) showed a strong positive correlation with anti-factor Xa activity across two different reagents (R=0.93 and R=0.91, p<0.001), whereas APTT correlation varied significantly by reagent.
Why the study?
Which coagulation test (PT or APTT) better correlates with anti-factor Xa activity in patients treated with edoxaban?
Cross-Sectional (n=80)
No
Which coagulation test (PT or APTT) better correlates with anti-factor Xa activity in patients treated with edoxaban?
Prothrombin time (PT) is more useful than APTT for evaluating anticoagulation in patients taking edoxaban due to its better correlation with anti-factor Xa activity.
PT may be preferable to APTT for edoxaban assessment; leaves open need for standardized assays before routine use.
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Nishimura et al. (2019) conducted a cross-sectional in Patients treated with edoxaban (n=80). Edoxaban was evaluated on Correlation between prothrombin time (PT) and anti-factor Xa activity (AXA) (R = 0.93 (Reagent A) and R = 0.91 (Reagent B), p=<0.001). In patients treated with edoxaban, prothrombin time (PT) showed a strong positive correlation with anti-factor Xa activity across two different reagents (R=0.93 and R=0.91, p<0.001), whereas APTT correlation varied significantly by reagent.
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