Relation of Residual Renal Function and Peritoneal Transport Rates with Arterial Stiffness in Peritoneal Dialysis Patients

Objective: It has been known that residual renal function (RRF) is preserved better in patients undergoing PD (peritoneal dialysis) therapy compared to HD patients. According to previous studies, in patients with high peritoneal transport rate (H-PTR) and decreased RRF, increased rates of cardiovascular (CV) morbidity and mortality have been demonstrated. The aim of this study is to identify the relationship between RRF and PTRs with arterial stiffness (AS) in PD patients. Methods: Seventy-five PD patients with a mean age of 53.713.3 years were included in this cross-sectional study. AS was determined by the measurement of brachial-ankle pulse wave velocity (baPWV). Patients were divided into two subgroups according to median baPWV and rGFR values. Multivariate analysis was performed to determine independent factors affecting rGFR and PTRs. Results: Fifty-six (74.6%) patients were treated by continuous ambulatory peritoneal dialysis (CAPD). According to PET, 48 (64%) patients had increased peritoneal permeability (H/ HA-PTR). Compared with low baPWV (8.0 m/sec) group, older age (p=0.000), systolic blood pressure (SBP) (p=0.000) and PD modality (p=0.002) were significantly higher in high baPWV (>8.0 m/sec) group. BaPWV, PTRs and PD modality were not different between the two groups (for all p>0.05). Age, rGFR,PD modality and baPWV were statistically similar between H-PTR and L-PTR groups (all p>0.05).In multivariate linear regression analysis; baPWV was independently associated with age (p=0.001) and SBP (p=0.001). In multivariate linear regression analysis; there was no relationship between rGFR and baPWV (p=0.751).