Key result
Peritoneal fluid transport rate (Ke) and extracellular water to total body water ratio were independent predictors of elevated carotid-femoral pulse wave velocity in CAPD patients (P<0.05 and P<0.01).
Why the study?
Is arterial stiffness associated with peritoneal fluid kinetics in continuous ambulatory peritoneal dialysis patients?
Cross-Sectional (n=65)
No
Is arterial stiffness associated with peritoneal fluid kinetics in continuous ambulatory peritoneal dialysis patients?
Effect estimate: r = 0.251
p-value: p=<0.05
Peritoneal fluid transport rate, extracellular water ratio, age, and pulse pressure are independent predictors of elevated arterial stiffness in CAPD patients, suggesting a link between high aortic stiffness and increased fluid absorption.
Peritoneal transport parameters associated with aortic stiffness in CAPD; hypothesis-generating for CV risk and needs prospective confirmation.
BACKGROUND: A high peritoneal transport status in continuous ambulatory peritoneal dialysis (CAPD) patients is associated with a markedly increased morbidity and mortality. While the causes are as yet unknown, overall the proportion of deaths due to cardiovascular disease is estimated at 40-50% among dialysis patients. Arterial stiffness has been established as a cardiovascular risk factor, while the links between peritoneal transport status and aortic stiffness have not yet been investigated. METHODS: We included 65 prevalent CAPD patients (24 males/41 females) from our center in a cross-sectional study. Arterial stiffness was assessed by brachial pulse pressure (PP) and carotid-femoral pulse wave velocity (C-F PWV). The patients' peritoneal fluid transport was assessed by kinetic modeling. The patients' peritoneal small solute transport rate was assessed by D/P(cr) at 4 h. Extracellular water to total body water (E/T) ratio was assessed by means of bioimpedance analysis. C-reactive protein was also measured. RESULTS: C-F PWV was positively correlated with patients' age (r = 0.489, p < 0.01), diabetic status (r = 0.327, p < 0.01), peritoneal fluid absorption rate (Ke; r = 0.251, p < 0.05), PP (r = 0.483, p < 0.01), and E/T (r = 0.517, p < 0.01). Multivariate regression analysis showed that C-F PWV was independently related to E/T (p < 0.01), PP (p < 0.01), age (p < 0.05), and Ke (p < 0.05). CONCLUSION: Peritoneal fluid transport (Ke), as well as E/T, age and PP were found to be independent predictors of elevated C-F PWV in CAPD patients, suggesting that there might be a link between high aortic stiffness and increased Ke rate, hypothetically through generalized vasculopathy.
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Zhe et al. (2007) conducted a cross-sectional in Continuous ambulatory peritoneal dialysis (CAPD) (n=65). Peritoneal fluid transport rate (Ke) was evaluated on Carotid-femoral pulse wave velocity (C-F PWV) (r = 0.251, p=<0.05). Peritoneal fluid transport rate (Ke) and extracellular water to total body water ratio were independent predictors of elevated carotid-femoral pulse wave velocity in CAPD patients (P<0.05 and P<0.01).
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