Systematic review demonstrates rare severe complications alongside mostly mild reactions across vaccinated populations, highlighting the need for individualized risk assessments.
INTRODUCTION: Yellow fever (YF) is a hemorrhagic viral infection that can be prevented by a highly effective live attenuated virus vaccine (YFV), which is not free from adverse reactions. This systematic review evaluated the burden of adverse events, including serious ones, due to vaccination. MATERIALS AND METHODS: This study was carried out following the guidelines of the Cochrane Collaboration and the Meta-analysis Of Observational Studies in Epidemiology, PRISMA 2020 checklist, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes. RESULTS: The suitable bibliography on PubMed/Medline, Scopus, and Web of Science was searched by combining text free, words and titles of medical topics. At the end of the search this systematic review contained 109 records. CONCLUSIONS: The YFV is safe, and serious adverse events are rare although they can be fatal and unpredictable. The most common adverse events are mild even in high-risk population groups. It is still advisable to assess the appropriateness of administration on a case-by-case basis.
No takes yet. Share an insight, caveat, or question.
Santangelo et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: