Key result
Quick Navi-Flu demonstrated higher sensitivities (86.8% vs 73.7% for influenza A; 85.7% vs 81.0% for B) and specificities than GOLD SIGN FLU for detecting influenza in adults.
Why the study?
Do GOLD SIGN FLU and Quick Navi-Flu accurately detect influenza A and B virus antigens compared to viral isolation in adults with influenza-like symptoms?
Observational (n=123)
Do GOLD SIGN FLU and Quick Navi-Flu accurately detect influenza A and B virus antigens compared to viral isolation in adults with influenza-like symptoms?
Quick Navi-Flu demonstrated better sensitivity and specificity than GOLD SIGN FLU for detecting influenza A and B in adults.
May favor Quick Navi-Flu for influenza antigen testing in adults; hypothesis-generating pending prospective validation.
As the characteristics and accuracy of rapid influenza detection tests (RIDTs) vary, the development of a high-performance RIDT has been eagerly anticipated. In this study, the new RIDT GOLD SIGN FLU and the existing RIDT Quick Navi-Flu were evaluated in terms of detecting the antigens of influenza viruses A and B in Japanese adults with influenza-like symptoms. The study was performed from December 2013 to March 2014. Among the 123 patients from whom nasopharyngeal swab specimens were collected, 59 tested positive by viral isolation as the gold standard method (influenza A, n=38; influenza B, n=21). For GOLD SIGN FLU, the sensitivities were 73.7% and 81.0%, and the specificities were 97.6% and 98.0% for influenza A and B, respectively. For Quick Navi-Flu, the sensitivities were 86.8% and 85.7%, and the specificities were 98.8% and 100% for influenza A and B, respectively. The time to the appearance of the line on the test strip was less than 3min for influenza A and less than 2min for influenza B with both RIDTs in more than 90% of cases. GOLD SIGN FLU was useful for diagnosing influenza A, and the result was readily available for influenza B particularly among adult patients. Quick Navi-Flu showed better sensitivities and specificities than GOLD SIGN FLU.
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Akaishi et al. (2016) conducted an observational in Influenza-like symptoms (n=123). GOLD SIGN FLU and Quick Navi-Flu vs. Viral isolation was evaluated on Detection of influenza A and B virus antigens (sensitivity and specificity). Quick Navi-Flu demonstrated higher sensitivities (86.8% vs 73.7% for influenza A; 85.7% vs 81.0% for B) and specificities than GOLD SIGN FLU for detecting influenza in adults.
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