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May 1, 2002Journal of Clinical MicrobiologyOpen Access

Evaluation of the Directigen FluA+B Test for Rapid Diagnosis of Influenza Virus Type A and B Infections

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Why the study?

Does the Directigen FluA+B test accurately diagnose influenza virus types A and B compared to culture and DFA in patients?

Population

250 patients providing nasopharyngeal aspirate specimens, predominantly children (80% ≤6 years old)

Comparison

Directigen FluA+B rapid test vs Culture and direct fluorescent antigen detection…

Design

Cross-sectional

Authors

KCKwok Hung ChanChinese University of Hong KongNMN. MaldeisWPWilliam T. PopeFlorida State University

Discussion

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Implication

May support rapid influenza detection; leaves open prospective validation against current standards.

Structured PICO

Does the Directigen FluA+B test accurately diagnose influenza virus types A and B compared to culture and DFA in patients?

P
Population
250 patients providing nasopharyngeal aspirate specimens, predominantly children (80% ≤6 years old)
I
Intervention
Directigen FluA+B rapid test
C
Comparator
Culture and direct fluorescent antigen (DFA) detection tests (with reverse transcription-PCR for discrepant results)
O
Outcome
Sensitivity, specificity, positive predictive value, and negative predictive value for influenza virus types A and Bsurrogate

The Directigen FluA+B test provides high sensitivity and specificity for the rapid detection of influenza A and B, though fresh specimens are preferred for optimal detection of influenza B.

Cite This Study

Chan et al. (2002) studied this question.

synapsesocial.com/papers/6a716f4a31a3df8243299ef4https://doi.org/10.1128/jcm.40.5.1675-1680.2002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Simultaneous Detection and Typing of Influenza Viruses A and B by a Nested Reverse Transcription-PCR: Comparison to Virus Isolation and Antigen Detection by Immunofluorescence and Optical Immunoassay (FLU OIA)2001 · 128 citations
  2. 2Simultaneous Detection of Influenza Viruses A and B Using Real-Time Quantitative PCR2001 · 458 citations
  3. 3Comparison of rapid detection methods for influenza A virus and their value in health-care management of institutionalized geriatric patients1994 · 102 citations
  4. 4Molecular characterization of H9N2 influenza viruses: Were they the donors of the “internal” genes of H5N1 viruses in Hong Kong?1999 · 747 citations
  5. 5Comparison of Directigen FLU-A with viral isolation and direct immunofluorescence for the rapid detection and identification of influenza A virus1991 · 120 citations