Key result
The Directigen Flu A+B rapid membrane enzyme immunoassay demonstrated an overall sensitivity of 43.83% and specificity of 99.74% for detecting influenza A and B viruses compared to viral culture.
Why the study?
Does the Directigen Flu A+B Membrane Enzyme Immunoassay accurately detect influenza A and B viruses compared to viral culture in patients with respiratory symptoms?
Population
4,092 respiratory specimens collected from patients presenting with respiratory symptoms during the…
Comparison
Directigen Flu A+B Membrane Enzyme Immunoassay vs Viral culture
Design
Cross-sectional
Authors
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Low sensitivity cautions against screening use; leaves open confirmatory utility pending prospective validation in current testing algorithms.
Cross-Sectional (n=4,092)
No
Does the Directigen Flu A+B Membrane Enzyme Immunoassay accurately detect influenza A and B viruses compared to viral culture in patients with respiratory symptoms?
Effect estimate: Sensitivity 43.83%, Specificity 99.74%
The Directigen Flu A+B assay has excellent specificity but low sensitivity, making it a good confirmatory test but a poor screening test for influenza.
Cazacu et al. (2004) conducted a cross-sectional in Suspected influenza / respiratory viral symptoms (n=4,092). Directigen Flu A+B Membrane Enzyme Immunoassay vs. Viral culture was evaluated on Overall sensitivity and specificity for detection of influenza A and B viruses (Sensitivity 43.83%, Specificity 99.74%). The Directigen Flu A+B rapid membrane enzyme immunoassay demonstrated an overall sensitivity of 43.83% and specificity of 99.74% for detecting influenza A and B viruses compared to viral culture.
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