Key result
The Directigen Flu A+B enzyme immunoassay detected only 16 (52%) of the 31 influenza A virus infections identified by cytospin-enhanced direct immunofluorescence in adults.
Why the study?
Does the Directigen Flu A+B enzyme immunoassay accurately detect influenza virus compared to cytospin-enhanced direct immunofluorescence in adults?
Population
152 nasopharyngeal swabs from adults evaluated in the emergency department after midnight
Comparison
Directigen Flu A+B enzyme immunoassay (EIA) vs Cytospin-enhanced direct immunofluorescence
Design
Cross-sectional
Authors
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Night-shift EIA may miss influenza cases; leaves open whether DFA or improved assays should guide 24-h ED testing.
Cross-Sectional (n=152)
No
Does the Directigen Flu A+B enzyme immunoassay accurately detect influenza virus compared to cytospin-enhanced direct immunofluorescence in adults?
Absolute Event Rate: 16% vs 31%
p-value: p=<0.0001
The rapid influenza EIA failed to detect almost half of the influenza cases in adults compared to cytospin-enhanced DFA, indicating suboptimal sensitivity in this population.
Landry et al. (2003) conducted a cross-sectional in Suspected influenza (n=152). Directigen Flu A+B enzyme immunoassay (EIA) vs. Cytospin-enhanced direct immunofluorescence (DFA) was evaluated on Detection of influenza A virus infections (p=<0.0001). The Directigen Flu A+B enzyme immunoassay detected only 16 (52%) of the 31 influenza A virus infections identified by cytospin-enhanced direct immunofluorescence in adults.
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