Key result
Patients with coronary artery ectasia had significantly higher mean platelet volume compared to controls (9.2 vs 8.8 fl; P<0.001).
Why the study?
Is mean platelet volume elevated in patients with coronary artery ectasia compared to controls?
Case-Control (n=526)
Is mean platelet volume elevated in patients with coronary artery ectasia compared to controls?
Absolute Event Rate: 9.2% vs 8.8%
p-value: p=<0.001
Mean platelet volume is significantly elevated in patients with coronary artery ectasia, suggesting increased platelet activation in this condition.
MPV elevation may reflect platelet activation in coronary artery ectasia; hypothesis-generating and requires prospective validation before clinical use.
Coronary artery ectasia (CAE) is a variant of coronary atherosclerosis. Mean platelet volume (MPV), an indicator of platelet activation, has been shown to be elevated in patients with acute coronary syndromes and myocardial infarction in the setting of obstructive coronary artery disease. The aim of this study was to assess the MPV in patients with CAE. We retrospectively studied 366 consecutive patients with CAE (195 men/171 women; mean age 55.4 +/- 10.9 years) and 160 control patients (81 men/79 women; mean age 53.5 +/- 10.2 years). MPV values were recorded in all study and control patients. The MPV values of patients with CAE were found to be significantly higher than those of the controls (9.2 +/- 1.1 versus 8.8 +/- 1.2 fl, respectively; P < 0.001). The platelet count was detected to be significantly lower in patients with CAE group than in patients with control group (233.7 +/- 70.7 versus 264.7 +/- 102.8 (x10(9)/l), respectively; P < 0.0001). We have shown that MPV was significantly elevated in patients with CAE compared with controls.
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Varol et al. (2009) conducted a case-control in Coronary artery ectasia (n=526). Coronary artery ectasia vs. Control patients was evaluated on Mean platelet volume (p=<0.001). Patients with coronary artery ectasia had significantly higher mean platelet volume compared to controls (9.2 vs 8.8 fl; P<0.001).
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