Platelet and erythrocyte indices, such as platelet count and mean corpuscular volume, significantly predict the ADP threshold dose required for platelet aggregation in whole blood.
Platelet and erythrocyte indices may influence ADP threshold interpretation in aggregation assays; this observational finding leaves open their role in guiding personalized antiplatelet strategies.
Variation in the threshold dose of ADP necessary to induce platelet aggregation in whole blood is significantly related to constituent factors of whole blood among 242 men from the Caerphilly Collaborative Heart Disease Study. Increased platelet count, mean platelet volume, and primary ADP-induced aggregation in platelet rich plasma are associated with lower ADP threshold doses, while increased red cell count and mean corpuscular volume are associated with higher ADP threshold doses. Marginal relations involving plasma fibrinogen concentration completely disappear upon taking into account the platelet indices. The platelet indices also appear to mediate relations between the ADP threshold dose and smoking status. Limitations in the data do not allow a more thorough assessment of how such constituents may mediate a relation between ADP threshold dose and past myocardial infarction. However, the analyses do not discount such an association for the platelet indices.
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Sharp et al. (1994) studied this question.
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