Key result
Baseline platelet hyperreactivity to ADP was significantly associated with incident myocardial infarction or stroke in a community-based cohort (HR 1.68; 95% CI 1.13-2.50; P=0.011).
Why the study?
Does baseline platelet hyperreactivity to ADP predict incident myocardial infarction or stroke in a community-based population free of CVD?
Population
2,831 community-based participants free of prevalent cardiovascular disease and without recent aspirin…
Comparison
Baseline platelet hyperreactivity to ADP vs Normal or lower platelet reactivity to ADP
Design
Cohort
Follow-up
median 20.4 years
Authors
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May refine primary CVD risk stratification; hypothesis-generating, with prospective trials needed before testing alters practice.
Cohort (n=2,831)
Does baseline platelet hyperreactivity to ADP predict incident myocardial infarction or stroke in a community-based population free of CVD?
Hazard Ratio: 1.68 (95% CI 1.13–2.5)
p-value: p=0.011
Intrinsic platelet hyperreactivity to low-dose ADP in individuals without known CVD or antiplatelet therapy predicts long-term risk of myocardial infarction or stroke.
Puurunen et al. (2018) conducted a cohort in Free of prevalent cardiovascular disease (n=2,831). Baseline platelet hyperreactivity to ADP vs. Normal reactivity or lower quartiles of ADP response was evaluated on Incident myocardial infarction or stroke (HR 1.68, 95% CI 1.13-2.50, p=0.011). Baseline platelet hyperreactivity to ADP was significantly associated with incident myocardial infarction or stroke in a community-based cohort (HR 1.68; 95% CI 1.13-2.50; P=0.011).
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