What does this research mean for the field?

Measures of platelet aggregation to thrombin and ADP in platelet-rich plasma are not significantly predictive of incident ischaemic heart disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1998HeartOpen Access

Platelet aggregation and incident ischaemic heart disease in the Caerphilly cohort

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Why the study?

Does platelet aggregation to thrombin and ADP predict incident ischaemic heart disease in middle-aged men?

Population

1,812 men aged 49-65 years from the Caerphilly cohort study

Design

Cohort

Follow-up

5 years

Authors

PEP C ElwoodGeneral / Preventive / Lipids SRS. RenaudCentre Hospitalier de Perpignan ABAndrew D BeswickUniversity of Bristol

Discussion

Member takes

Implication

Does not support platelet aggregation testing for IHD prediction in middle-aged men; leaves open its value with other assays or populations.

Structured PICO

Does platelet aggregation to thrombin and ADP predict incident ischaemic heart disease in middle-aged men?

Population

1,812 men aged 49-65 years from the Caerphilly cohort study (initial n=2,176, with 364 excluded due to non-fasting or recent antiplatelet medication use)

Intervention

Measurement of platelet aggregation to thrombin and ADP in platelet rich plasma

Outcome

Incident ischaemic heart disease (IHD) events (fatal and non-fatal) fulfilling World Health Organisation criteriahard clinical

Platelet aggregation to thrombin and ADP does not significantly predict incident ischaemic heart disease in middle-aged men over a 5-year follow-up.

Cite This Study

Elwood et al. (1998) studied this question.

synapsesocial.com/papers/6a1bc2dd69a4af5b15a8f3ba https://doi.org/10.1136/hrt.80.6.578

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Implication

Does not support platelet aggregation testing for IHD prediction in middle-aged men; leaves open its value with other assays or populations.

Platelet aggregation and incident ischaemic heart disease in the Caerphilly cohort

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Platelet aggregation and incident ischaemic heart disease in the Caerphilly cohort

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider