Population
Rat striated muscle alpha-tropomyosin mutants
Comparison
Deletion or replacement of individual periodic… vs Wild-type or other mutant tropomyosins
Design
Preclinical
Authors
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Tropomyosin repeats have specialized regulatory roles; leaves open in vivo validation and relevance to cardiac disease models.
Internal periodic repeats of tropomyosin are not quasi-equivalent, with specific regions like period 5 being critical for actin affinity and period 6 for ATPase inhibition.
Hitchcock‐DeGregori et al. (2002) studied this question.