Key result
Quercetin was the most effective therapeutic candidate for doxorubicin-induced chronic kidney disease in a rat model, whereas naringenin, rutin, and catechin did not ameliorate the condition.
Why the study?
Do nutraceutics (naringenin, catechin, quercetin, rutin) improve doxorubicin-induced chronic kidney disease in a rat model?
Do nutraceutics (naringenin, catechin, quercetin, rutin) improve doxorubicin-induced chronic kidney disease in a rat model?
In a rat model of doxorubicin-induced CKD, quercetin demonstrated partial to complete efficacy in ameliorating renal, cardiovascular, and biochemical abnormalities, whereas naringenin, rutin, and catechin were ineffective.
Quercetin merits further preclinical study in doxorubicin-induced CKD; animal data leave human translation unresolved.
SCOPE: The number of patients with chronic kidney disease (CKD) are increasing. Interventions such as controlling hypertension and specific pharmacologic options are recommended. Some nutraceutics may have benefits in this regard. METHODS AND RESULTS: Naringenin (a flavanon), catechin (a flavanol), and quercetin (a flavonol) and rutin (a flavonol rutinoside) were tried on CKD in a Sprague Dawley rat model. Results indicated quercetin to be the most effective therapeutic candidate with respect to renal edema, hypertension, serum creatinine, hematocrit, cardiopathy, aorta calcification, glomerular amyloidosis, erythrocyte depletion in bone marrow, collagen deposition, expressions of TNF-α, cleaved caspase-3, IκBα, PPARα, and serum insulin. But quercetin was only partially effective in restoring glomerular filtration rate, albuminuria, serum cholesterol, triglyceride, blood urea nitrogen (BUN), uric acid, malondialdehyde, superoxide dismutase; urinary BUN and urinary creatinine. As for signaling, quercetin was completely effective in alleviating the cleaved caspase-3, being only partially effective in suppressing Bax and Bad, restoring Bcl-2, and rescuing DNA damage. CONCLUSION: The CKD status cannot to be ameliorated by naringenin, rutin, and catechin. Comparatively, quercetin may be a better therapeutic candidate.
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Peng et al. (2012) studied doxorubicin-induced chronic kidney disease. Quercetin, naringenin, catechin, and rutin was evaluated on therapeutic effects on CKD parameters. Quercetin was the most effective therapeutic candidate for doxorubicin-induced chronic kidney disease in a rat model, whereas naringenin, rutin, and catechin did not ameliorate the condition.
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