Key result
Early postmenopausal status was associated with significant sympathovagal imbalance, including reduced HFnu and RMSSD and increased LFnu and LF:HF ratio, compared to premenopausal women.
Why the study?
Menopausal transition includes various autonomic dysfunctions and age affects autonomic function, prompting assessment of the effect of menopause on autonomic function by comparing heart rate variability between early postmenopausal and late premenopausal women.
Does the early postmenopausal state alter heart rate variability compared to the late premenopausal state in women aged 40-55 years?
Cross-Sectional
Does the early postmenopausal state alter heart rate variability compared to the late premenopausal state in women aged 40-55 years?
Early postmenopausal women exhibit sympathovagal imbalance characterized by increased sympathetic and decreased parasympathetic activity, which may contribute to increased cardiovascular risk.
HRV differences around menopause merit prospective confirmation; leaves open independent effects beyond age on autonomic risk.
Background and Aim: Menopause marks to a point in time that follows after the permanent stoppage of menstruation. Menopausal transition includes various autonomic dysfunctions. Age is known to affect autonomic function. Therefore, in the present study the effect of menopause on autonomic function has been assessed by comparing the heart rate variability parameters between early postmenopausal and late premenopausal women. Methods: Premenopausal and postmenopausal women of age group between 40-55 years were recruited and short term HRV was measured using BIOPAC and analysed with kubios software. Results: In postmenopausal women, HFnu was significantly reduced, LFnu, LF: HF ratio were significantly increased and among the time domain parameters, RMSSD was significantly reduced in postmenopausal women. Conclusion: Sympathovagal imbalance in the form of increased sympathetic and decreased parasympathetic activity was found in early postmenopausal women. There was considerable decrease in vagal indices in postmenopausal women which is known to increase cardiovascular risks.
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Subhashri et al. (2019) conducted a cross-sectional in Menopause. Early postmenopausal status vs. Late premenopausal status was evaluated on Heart rate variability parameters (HFnu, LFnu, LF:HF ratio, RMSSD). Early postmenopausal status was associated with significant sympathovagal imbalance, including reduced HFnu and RMSSD and increased LFnu and LF:HF ratio, compared to premenopausal women.
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