Why the study?
Does captopril improve physical work capacity and reduce ischemia during exercise in normotensive patients with stable effort-induced angina pectoris?
Does captopril improve physical work capacity and reduce ischemia during exercise in normotensive patients with stable effort-induced angina pectoris?
A single 50 mg oral dose of captopril improves exercise tolerance and reduces ischemic signs in normotensive patients with stable angina.
Single-dose captopril may improve exercise tolerance in stable angina; leaves open whether chronic ACE inhibition alters outcomes in normotensives.
Twelve normotensive patients with coronary artery disease and stable effort-induced angina pectoris were selected: the antiischemic effect of captopril was studied. A maximal cycloergometer effort test was obtained before (base) and after administration of placebo or captopril (50 mg p.o.). The following parameters were measured: heart rate (HR), blood pressure (BP), maximal rate/pressure product (MRPP), maximal workload sustained, (MWS), maximal working time (MWT), and S-T depression at MRPP. The base and placebo were similar. Compared to them captopril augmented the MWT, increased the MWS, reduced S-T depression at MRPP, and decreased the number of patients with effort-induced angina pectoris. The antiischemic effect of captopril seems related both to its effect on HR and BP, and to a local enhancement of coronary blood flow.
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Strozzi et al. (2008) studied this question.
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