February 3, 2007AJP Cell Physiology

Function of Kv1.5 channels and genetic variations ofKCNA5in patients with idiopathic pulmonary arterial hypertension

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Population

Human pulmonary artery smooth muscle cells, other cell lines, and patients with idiopathic pulmonary…

Design

Preclinical

Authors

CRCarmelle V. RemillardHologic (United States)DTDonna D. TignoUniversity of California, San Diego OPOleksandr PlatoshynVascular / Pulmonary Vascular

Discussion

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Implication

KCNA5 SNPs in IPAH suggest possible channel dysfunction; hypothesis-generating and should not yet inform clinical testing or therapy.

Structured PICO

Population

Human pulmonary artery smooth muscle cells (PASMC), other cell lines, and patients with idiopathic pulmonary arterial hypertension (IPAH)

Intervention

Overexpression of KCNA5 gene and extracellular application of nicotine, bepridil, correolide, and endothelin-1 (ET-1)

Outcome

Kv1.5 channel currents and identification of single-nucleotide polymorphisms (SNPs) in KCNA5surrogate

Kv1.5 channels are modulated by various agonists and novel SNPs in KCNA5 are present in IPAH patients, potentially underlying altered channel expression or function in this disease.

Cite This Study

Remillard et al. (2007) studied this question.

synapsesocial.com/papers/6a91ac0e059e6373bdf594b0 https://doi.org/10.1152/ajpcell.00405.2006

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Function of Kv1.5 channels and genetic variations ofKCNA5in patients with idiopathic pulmonary arterial hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Function of Kv1.5 channels and genetic variations ofKCNA5in patients with idiopathic pulmonary arterial hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider