Matrix Metalloproteinases in Hypertensive Heart Disease: New Mechanistic Insights

Berk BC, Fujiwara K, Lehoux S : ECM remodeling in hypertensive heart disease. J Clin Invest 2007; 117 : 568–575. Article CAS Google Scholar Iwanaga Y, Aoyama T, Kihara Y, et al : Excessive activation of matrix metalloproteinases coincides with left ventricular remodeling during transition from hypertrophy to heart failure in hypertensive rats. J Am Coll Cardiol 2002; 39 : 1384–1391. Article CAS Google Scholar Mujumdar VS, Smiley LM, Tyagi SC : Activation of matrix metalloproteinase dilates and decreases cardiac tensile strength. Int J Cardiol 2001; 79 : 277–286. Article CAS Google Scholar Matsusaka H, Ide T, Matsushima S, et al : Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload. Hypertension 2006; 47 : 711–717. Article CAS Google Scholar Heymans S, Lupu F, Terclavers S, et al : Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. Am J Pathol 2005; 166 : 15–25. Article CAS Google Scholar Lin J, Davis HB, Dai Q, et al : Effects of early and late chronic pressure overload on extracellular matrix remodeling. Hypertens Res 2008; 31 : 1225–1231. Article CAS Google Scholar Hinojosa-Laborde C, Craig T, Zheng W, et al : Ovariectomy augments hypertension in aging female Dahl salt-sensitive rats. Hypertension 2004; 44 : 405–409. Article CAS Google Scholar Ahmed SH, Clark LL, Pennington WR, et al : Matrix metalloproteinases/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structural, functional, and clinical manifestations of hypertensive heart disease. Circulation 2006; 113 : 2089–2096. Article CAS Google Scholar Ishikawa J, Kario K, Matsui Y, et al : Collagen metabolism in extracellular matrix may be involved in arterial stiffness in older hypertensive patients with left ventricular hypertrophy. Hypertens Res 2005; 28 : 995–1001. Article CAS Google Scholar Chapman RE, Spinale FG : Extracellular protease activation and unraveling of the myocardial interstitium: critical steps toward clinical applications. Am J Physiol Heart Circ Physiol 2004; 286 : H1–H10. Article CAS Google Scholar Hudson MP, Armstrong PW, Ruzyllo W, et al : Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial. J Am Coll Cardiol 2006; 48 : 15–20. Article CAS Google Scholar Download references