Why the study?
Due to concerns regarding brain deposition of gadolinium, non-contrast CMR methods for detecting and monitoring myocardial fibrosis in Duchenne muscular dystrophy would be beneficial.
Can non-contrast CMR methods (native T1 mapping and strain) accurately detect myocardial fibrosis compared to LGE in boys with Duchenne muscular dystrophy?
Population
66 DMD boys undergoing 156 CMRs with gadolinium
Comparison
Native T1 mapping and strain vs LGE
Authors
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Strain may enable gadolinium-free fibrosis monitoring in DMD; hypothesis-generating without incremental value over LVEF.
Can non-contrast CMR methods (native T1 mapping and strain) accurately detect myocardial fibrosis compared to LGE in boys with Duchenne muscular dystrophy?
Non-contrast CMR sequences like strain and native T1 mapping can predict the presence and severity of myocardial fibrosis in DMD, but currently do not replace LGE.
Raucci et al. (2021) studied this question.
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