What question did this study set out to answer?

To determine how geographical location influences the development and diversity of the gut microbiome in infants carrying homogenous HLA class II genotypes associated with high risk for type 1 diabetes.

December 17, 2014Diabetes CareOpen Access

Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes

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Authors

KKKaisa KemppainenUniversity of Florida AAAlexandria N. ArdissoneUniversity of Florida ADAustin G. Davis‐RichardsonCodexis (United States)

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Implication

Pilot cohort study reveals strong geographic differences in gut microbiomes among infants at risk for type 1 diabetes, indicating that location shapes early bacterial colonization.

Key Points

To determine how geographical location influences the development and diversity of the gut microbiome in infants carrying homogenous HLA class II genotypes associated with high risk for type 1 diabetes.
Analyzed stool samples from 90 high-risk, nonautoimmune infants enrolled in the TEDDY study across four countries: the U.S., Germany, Sweden, and Finland.
Profiled longitudinal bacterial communities using high-throughput 16S rRNA gene sequencing.
Bacterial community diversity over time differed significantly by geographic location, with infants from Finland and Colorado displaying significantly lower diversity.
Early-life microbiota exhibited site-specific taxonomic patterns across continents, such as a strong dominance of Bifidobacterium in cohorts from Sweden and Washington state.

Cite This Study

Kemppainen et al. (2014) studied this question.

synapsesocial.com/papers/6a91b46ec003a8065c078584 https://doi.org/10.2337/dc14-0850

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Implication

Pilot cohort study reveals strong geographic differences in gut microbiomes among infants at risk for type 1 diabetes, indicating that location shapes early bacterial colonization.

Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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