What question did this study set out to answer?

To evaluate the demographic, clinical, and pathologic features that influence disease-specific survival in patients diagnosed with small cell carcinoma of the urinary bladder.

January 15, 1992CancerOpen Access

Small cell carcinoma of the urinary bladder. A clinicopathologic analysis of 22 cases

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Authors

DGDavid J. GrignonAmerican College of Radiology JRJae Y. RoInje University AAAlberto G. AyalaThe University of Texas MD Anderson Cancer Center

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Implication

Retrospective cohort study reveals poor survival and high rates of muscle invasion in bladder small cell carcinoma, highlighting the aggressive nature of this malignancy.

Key Points

To evaluate the demographic, clinical, and pathologic features that influence disease-specific survival in patients diagnosed with small cell carcinoma of the urinary bladder.
Reviewed histologic slides and medical records of N=64 patients diagnosed according to World Health Organization criteria.
Staged tumors via the 2002 TNM classification and evaluated correlations between clinicopathologic characteristics and survival over a mean follow-up of 21 months.
Muscle-invasive disease occurred in all but one patient, 66% had lymph node metastasis at cystectomy (N=38), and 68% presented with mixed histology.
Disease-specific survival was 56% at 1 year, 41% at 18 months, 23% at 3 years, and 16% at 5 years.
Survival did not differ significantly between patients treated with or without cystectomy (P = 0.65), whereas organ-confined status showed borderline survival benefit (P = 0.06).

Cite This Study

Grignon et al. (1992) studied this question.

synapsesocial.com/papers/6a9224ec43dadb0f154358ff https://doi.org/10.1002/1097-0142(19920115)69:2<527::aid-cncr2820690241>3.0.co;2-7

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Implication

Retrospective cohort study reveals poor survival and high rates of muscle invasion in bladder small cell carcinoma, highlighting the aggressive nature of this malignancy.

Small cell carcinoma of the urinary bladder. A clinicopathologic analysis of 22 cases

Discussion

Member takes

Implication

Key Points

Cite This Study

Small cell carcinoma of the urinary bladder. A clinicopathologic analysis of 22 cases

Discussion

Member takes

Implication

Key Points

Cite This Study

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