The Significance of Post-Prandial Glycosuria in the Treatment of Diabetes Mellitus With Protamine Zinc Insulin

Article1 September 1939THE SIGNIFICANCE OF POST-PRANDIAL GLYCOSURIA IN THE TREATMENT OF DIABETES MELLITUS WITH PROTAMINE ZINC INSULINI. M. RABINOWITCH, F.A.C.P.I. M. RABINOWITCH, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-3-385 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptProtamine zinc insulin is now a definitely established therapeutic agent for the treatment of diabetes mellitus. Judging from the literature, most of the difficulties which were met with, following our first reports1, 2, 3of the product now in general use†appear to have been overcome. Theoretically, protamine zinc insulin appeared to be. contraindicated in conditions for which quick action is necessary, though this also was contrary to our experiences. Coma is an example. Because of its slow action in ordinary amounts, it was repeatedly stated in the literature that protamine zinc insulin is contraindicated in coma. Actually, as...References1. RABINOWITCHFOSTERFOWLERCORCORAN IMJSAFAC: Clinical experiences with protamine zinc insulin and other mixtures of zinc and insulin in diabetes mellitus, Canad. Med. Assoc. Jr., 1936, xxxv, 239. Google Scholar2. RABINOWITCHFOWLERCORCORAN IMAFAC: Further observations on the use of protamine zinc insulin in diabetes mellitus, Canad. Med. Assoc. Jr., 1937, xxxv, 111. Google Scholar3. FOWLERBENSLEYRABINOWITCH AFEHIM: Control of diabetes mellitus with protamine zinc insulin in surgery, Canad. Med. Assoc. Jr., 1937, xxxvi, 561. Google Scholar4. RABINOWITCHFOWLERBENSLEY IMAFEH: The use of protamine zinc insulin in diabetic coma, Canad. Med. Assoc. Jr., 1937, xxxvii, 105. Google Scholar5. RABINOWITCH IM: The diagnosis of diabetes, Trans. Assoc. Life Ins. Med. Dir. N.A., 1933, xx, 9. Google Scholar6. 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Author, Article, and Disclosure InformationAffiliations: Montreal, Canada*Received for publication August 16, 1938.From the Department of Metabolism, The Montreal General Hospital, Montreal, Canada.†Though attempts had been made by other workers to prolong the action of insulin and of Hagedorn's protamine insulin, the product upon which these reports were based was that first prepared by Scott and Fisher in the Connaught Laboratories, of the University of Toronto, and supplied to this hospital for clinical trial. It is the protamine zinc insulin which is now in general use. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1939Volume 13, Issue 3Page: 385-393KeywordsClinical trial reportingComaDiabetes mellitusInsulinProtaminesZinc ePublished: 1 December 2008 Issue Published: 1 September 1939 Copyright & PermissionsCopyright, 1939, by The American College of PhysiciansPDF downloadLoading ...